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An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
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Leishmania-HIV interaction: immunopathogenic mechanisms

D Wolday1, N Berhe, H Akuffo

  • 1Armauer Hansen Research Institute, Addis Ababa, Ethiopia. ahri@telecom.net.et

Parasitology Today (Personal Ed.)
|May 14, 1999
PubMed

Both Leishmania and the human immunodeficiency virus (HIV) can infect and multiply in macrophages, and both can dysregulate the immune system. Recent studies indicate that Leishmania can induce the activation of HIV in latently infected monocytic and T cells. Moreover, HIV can enhance intracellular growth of Leishmania in macrophages. Here, Dawit Wolday and colleagues examine the mechanisms that might be involved in the immunopathogenesis of Leishmania- HIV co-infection.

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