Effect on carbohydrate metabolism of hypotensive adrenergic neurone blocking agents

In subjects with normal metabolism sugar tolerance was not appreciable influenced by 4 or 5-day courses of guanethidine and guanazodine. Upon perfusion in isolated rat liver, glycogen metabolism and hepatic sugar release were increased by guanazodine, guanethidine and debrisoquine alike. However, when these drugs were used simultaneously with chlorpropamide debrisoquine proved to be the weakest in counteracting the inhibitory effect of chlorpropamide on glycogen metabolism and sugar release. The observation may have clinical significance.