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Updated: Aug 1, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Ligand-independent Activation of Steroid Receptors: New Roles for Old Players
1Département de Biologie Cellulaire, Université de Geneve, Sciences III, 30 Quai Ernest-Ansermet, 1211 Geneveve 4, Switzerland.
Abstract:
Steroid receptors are known as ligand-regulated transcription factors, but more and more evidence indicates that several steroid receptors can be activated in the absence of cognate hormone by agents that fall into three separate groups: peptide growth factors, the neurotransmitter dopamine and other agents that activate cAMP-dependent protein kinase A, and the cyclins A and D1.
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