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Related Experiment Videos

The WD repeat: a common architecture for diverse functions.

T F Smith1, C Gaitatzes, K Saxena

  • 1Boston University, Biomolecular Engineering Research Center, Boston, MA 02215, USA. tsmith@darwin.bu.edu

Trends in Biochemical Sciences
|May 14, 1999
PubMed
Summary
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WD repeat proteins, crucial for eukaryotes, are classified into subfamilies based on structural similarity. This classification aids in predicting their binding partners and functions.

Area of Science:

  • Molecular Biology
  • Structural Biology
  • Biochemistry

Background:

  • WD repeat proteins are a large, functionally diverse protein family found across all eukaryotes.
  • These proteins are involved in numerous essential cellular processes.
  • Accumulating knowledge highlights their significance in biological systems.

Purpose of the Study:

  • To define subfamilies within the WD repeat protein family.
  • To leverage structural information for functional predictions.
  • To understand the evolutionary and functional relationships among WD repeat proteins.

Main Methods:

  • Determining the three-dimensional structure of a representative WD repeat protein.
  • Assuming structural conservation across the WD repeat protein family.

Related Experiment Videos

  • Classifying WD repeat proteins into subfamilies based on surface similarity analysis.

    • Main Results:

    • A method for defining WD repeat protein subfamilies was established.
    • Structural insights allowed for the grouping of proteins with similar surface characteristics.
    • Subfamilies were identified based on probable surface similarity.

    Conclusions:

    • WD repeat protein structure is likely conserved, enabling subfamily classification.
    • Proteins with similar surface structures are predicted to share binding partners and functions.
    • This structural classification provides a framework for understanding WD repeat protein diversity and function.