Effects of prostaglandins upon hair growth in mice

The effect of prostaglandins upon the diffuse hair wave induced by gonadectomy was studied in male C3H mice. The drugs used were Prostaglandin E1 and Prostaglandin F2alpha, tromethamine salt, which were administered twice a day intraperitoneally during 22 days, in daily doses from 1 to 6 micrograms. The animals had their back clipped and were castrated at the beginning of each experiment. At the end of the 22 day experimental period while all the castrated control mice were completely covered by hair, in the castrated prostaglandin treated mice a marked inhibition of the hair growth was noticed.