Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kidney development branches out.

G R Dressler1

  • 1Department of Pathology, University of Michigan, Ann Arbor 48109, USA. dressler@umich.edu

Developmental Genetics
|May 14, 1999
PubMed
Summary
This summary is machine-generated.

The developing kidney is a key model for studying epithelial-mesenchymal interactions. Advances in renal development research offer insights into the genetic causes of kidney diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kielin/Chordin-Like Protein-A Novel Pathway to Prevent Renal Fibrosis?: Kielin/Chordin-Like Protein, a Novel Enhancer of BMP Signaling, Attenuates Renal Fibrotic Disease. Nat Med 11: 387-393, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Another niche for Notch.

Kidney international·2008
Same author

Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene.

Development (Cambridge, England)·2001
Same author

PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.

Nucleic acids research·2000
Same author

Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons.

Developmental biology·2000
Same author

Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease.

Developmental biology·2000
Same journal

A Message From the Editor.

Developmental genetics·1999
Same journal

Telomerase activity and telomere detection during early bovine development.

Developmental genetics·1999
Same journal

Maternal function of a retroviral-type zinc-finger protein is essential for Drosophila development.

Developmental genetics·1999
Same journal

Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs.

Developmental genetics·1999
Same journal

Spatial pattern of constitutive and heat shock-induced expression of the small heat shock protein gene family, Hsp30, in Xenopus laevis tailbud embryos.

Developmental genetics·1999
Same journal

Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways.

Developmental genetics·1999
See all related articles

Area of Science:

  • Developmental Biology
  • Nephrology
  • Genetics

Background:

  • The developing kidney has been a model for epithelial-mesenchymal interactions for over 40 years.
  • Modern genetic and biochemical tools are now being used to study kidney development principles.

Purpose of the Study:

  • To review recent progress in renal development research.
  • To discuss the potential of various model systems in studying kidney organogenesis.
  • To highlight the connection between renal development and the genetic basis of kidney diseases.

Main Methods:

  • Review of papers presented in a special issue.
  • Discussion of mammalian kidney organ culture models.
  • Investigation using zebrafish and Xenopus laevis models.

Related Experiment Videos

Main Results:

  • Significant progress has been made in understanding inductive signaling, epithelial cell differentiation, and pattern formation in the kidney.
  • Zebrafish and Xenopus laevis models show promise for studying kidney organogenesis in vivo.
  • Advances in renal development research are increasingly illuminating the genetic underpinnings of kidney diseases.

Conclusions:

  • The study of kidney development continues to evolve with new tools and model systems.
  • Understanding renal development is crucial for deciphering the genetic basis of kidney diseases.
  • Interdisciplinary approaches combining genetics, biochemistry, and model organisms are advancing the field.