[Relationship of serum trace elements to lung cancer and its clinical application]

The levels of serum trace elements Cu, Zn, Fe, Mn and Ca were measured by PE3030 atomic absorption spectrophotometer in 300 patients with lung cancer, 50 with nonmalignant pulmonary diseases and 100 healthy subjects. In addition, these trace elements were also measured in 60 cases with lung cancer (40 remitted, 20 non-remitted) before and after treatment. Results showed that the concentrations of serum Cu, Mn and Cu/Zn ratio were significantly higher (P < 0.01) but Zn, Ca were significantly lower (P < 0.05-0.01) in lung cancer and nonmalignant pulmonary diseases than in healthy controls. Within the three groups there has no difference among profession, area and age discovered. In the remitted patients with lung cancer, the levels of serum Cu and Cu/Zn ratio were significantly lower (P < 0.01) but Zn, Ca were significantly higher (P < 0.01) after treatment. In the non-remitted group, only Cu/Zn ratio was significantly higher (P < 0.01) after treatment. Multivariable logistic regression analysis showed that the Odds Ratio (OR) of serum Ca was 0.9950 with 95% Confidence interval (CI) 0.9910-0.9990, and the OR of Cu/Zn was 7.9914 with 95% CI 3.4310-18.6134. It was suggested that Ca might play a protective vole while Cu/Zn ratio a risk factor for lung cancer. Results also showed that if the threshold of Cu/Zn ratio set at 1.10 in the healthy control group, the positive rate of Cu/Zn ratio was 68% which might be important in diagnosis and to assessing the prognosis of lung cancer.