[Effects of carbon disulfide on neurotransmitter and its metabolites in rats]

Y Gao¹, L Ge, Y Liang

¹Department of Occupational Health, Shanghai Medical University.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]

|May 14, 1999

Abstract

Objective:

In order to study the mechanism of neurotoxic effects of carbon disulfide (CS2) on animal behavior.

Methods:

Changes in monoamine transmitter, amino acid transmitter and their metabolites in brain tissues were observed in rats exposed to CS2 at levels of 0, 1,200 and 2,400 mg/m3 respectively, for two months, with high performance liquid chromatography.

Results:

Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior.

Conclusion:

Disturbance of neurotransmitter metabolism plays an important role in neurotoxic effects of CS2.

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Objective:

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Conclusion:

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