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[Antimutagenic mechanism of kiwifruit juice]

S Li1, L Shang, H Xu

  • 1Department of Toxicology, Beijing Medical University.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|May 14, 1999
PubMed
Abstract

Insights

Kiwifruit juice reduced cyclophosphamide-induced mutagenicity in rats by boosting detoxifying enzymes like glutathione-S-transferase (GST) and uridine diphosphate glucuronyltransferase (UDPGT). This suggests kiwifruit juice has antimutagenic properties.

Area of Science:

  • Toxicology
  • Biochemistry
  • Nutritional Science

Context:

  • Cyclophosphamide (CP) is a known mutagen.
  • Biotransformation enzymes play a crucial role in detoxification.
  • Micronucleus formation is a marker of genotoxicity.

Purpose:

  • To investigate the antimutagenic potential of kiwifruit juice.
  • To assess the impact of kiwifruit juice on key biotransformation enzymes.
  • To explore the relationship between enzyme activity and reduced mutagenicity.

Summary:

  • Kiwifruit juice significantly inhibited cyclophosphamide-induced micronucleus formation in rat lymphocytes.
  • Administration of kiwifruit juice led to a significant increase in the activity of liver glutathione-S-transferase (GST) and uridine diphosphate glucuronyltransferase (UDPGT).
  • A negative correlation was observed between the rate of micronucleated cells and the activity of GST and UDPGT.

Impact:

  • Kiwifruit juice demonstrates antimutagenic effects.
  • The observed effects are likely mediated by enhanced activity of detoxifying enzymes.
  • Findings suggest a potential role for kiwifruit in mitigating chemically induced genotoxicity.

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