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[The correlation between abusing alcohol and antioxidants, antioxidases].

J Zhou1, Y Du, Y Wang

  • 1The 2nd Hospital of Zhejiang Medical University, Hangzhou.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|May 14, 1999
PubMed
Summary

Alcohol abuse significantly depletes key antioxidants and enzymes like vitamin C, vitamin E, beta-carotene, superoxide dismutase, catalase, and glutathione peroxidase. This imbalance exacerbates oxidative stress in alcohol abusers.

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Toxicology

Context:

  • Alcohol abuse is a widespread issue with significant health implications.
  • Oxidative stress plays a crucial role in the pathophysiology of alcohol-related diseases.
  • Antioxidant defense systems are vital for mitigating cellular damage.

Purpose:

  • To investigate the relationship between alcohol consumption and the levels of key antioxidants and antioxidant enzymes.
  • To assess the impact of alcohol abuse on the body's ability to combat oxidative stress.

Summary:

  • This study measured plasma vitamin C (P-VC), vitamin E (P-VE), beta-carotene (P-beta-CAR), and erythrocyte superoxide dismutase (E-SOD), catalase (E-CAT), and glutathione peroxidase (E-GSH-Px) activities in male alcohol abusers and non-drinkers.
  • Results indicated significantly lower levels of all measured antioxidants and enzymes in the alcohol abuser group compared to non-drinkers.

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  • Furthermore, antioxidant and enzyme levels decreased proportionally with increased duration and quantity of alcohol consumption.

    • Impact:

    • Alcohol abuse leads to a pathological exacerbation of oxygen free radical reactions.
    • Chronic alcohol consumption results in a severe imbalance between oxidation and antioxidation, increasing cellular damage.
    • Findings highlight the detrimental effect of alcohol on the body's antioxidant defense mechanisms, contributing to alcohol-related pathologies.