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[A prospective study on post-transfusion hepatitis G virus infection]
1Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou.
Summary
Hepatitis G virus (HGV) infection was studied in blood transfusion patients. Simple HGV infections showed no clinical signs or elevated ALT, challenging its role as a significant hepatitis virus.
Area of Science:
- Virology
- Hepatology
- Infectious Diseases
Background:
- Post-transfusion hepatitis remains a concern, with Hepatitis B (HBV) and C (HCV) being well-established causes.
- The role of Hepatitis G virus (HGV) in post-transfusion hepatitis is less understood and requires further investigation.
Purpose of the Study:
- To determine the incidence of Hepatitis G virus (HGV) infection following blood transfusions.
- To investigate the relationship between HGV infection and co-infections with Hepatitis B (HBV) and Hepatitis C (HCV).
Main Methods:
- Detection of HBV and HCV markers (antigens, antibodies, RNA) and HGV RNA using nested reverse transcription polymerase chain reaction (RT-PCR).
- Analysis of 138 patients undergoing blood transfusion, with samples collected pre- and post-operation.
- Examination of residual donor blood samples for HGV RNA.
Main Results:
- Out of 53 post-transfusion hepatitis cases, 48 were HCV and two were HBV (one co-infection).
- HGV RNA was detected in seven patients via RT-PCR, with three co-infected with HCV and elevated ALT.
- Patients with simple HGV infection had normal ALT levels, and HGV RNA was detectable for 1-6 months.
Conclusions:
- Simple HGV infection in blood donors and recipients did not present with clinical hepatitis or elevated ALT.
- These findings suggest HGV may not be a significant cause of hepatitis, contrary to some existing views.
- Further research is needed to fully elucidate the clinical significance of HGV.