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[Experimental study on effect of zhuyu tongfu mixture on anti-enterogenous infection caused by endotoxin]
Objective:
To evaluate the effect of Zhuyu Tongfu mixture (ZYTFM) in curing enterogenus infection.
Methods:
Experimental model of enterogenous infection in mice caused by endotoxin was used. The positive translocation trate (PTR) and mumber of viable bacteria in viscera and serum level of superoxide dismutase (SOD) were measured before and after ZYTFM treatment.
Results:
The PTR and number of viable bacteria in liver, spleen and mesocolon in the ZYTFM group were much lower than those in the model group and the placebo group (P < 0.01). Whereas the SOD level of the ZYTFM group was significantly higher than that in the latter two groups (P < 0.05-0.01). Pathological examination displayed that ZYTFM could markedly alleviate the mucosal damage of small intestine.
Conclusion:
ZYTFM has an obvious curative effect on enterogenous infections induced by endotoxin.
Insights
Zhuyu Tongfu mixture (ZYTFM) effectively treats endotoxin-induced enterogenous infections in mice. This traditional formula reduced bacterial translocation and improved antioxidant levels, aiding intestinal healing.
Area of Science:
- Traditional Chinese Medicine
- Infectious Diseases
- Immunology
Context:
- Enterogenous infections pose significant health risks.
- Endotoxins are key triggers of these infections.
- Developing effective treatments is crucial.
Purpose:
- To evaluate the therapeutic effect of Zhuyu Tongfu mixture (ZYTFM) on enterogenous infections.
- To assess ZYTFM's impact on bacterial translocation and oxidative stress.
Summary:
- An experimental model of endotoxin-induced enterogenous infection in mice was utilized.
- ZYTFM treatment significantly reduced positive translocation rate and viable bacteria in viscera.
- ZYTFM increased superoxide dismutase (SOD) levels and alleviated intestinal mucosal damage.
Impact:
- ZYTFM demonstrates a clear curative effect on endotoxin-induced enterogenous infections.
- The findings support ZYTFM as a potential therapeutic agent for such conditions.
- This research contributes to understanding ZYTFM's efficacy in managing complex infections.
