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[Effect of jishentang on renal lesions in diabetic rats]
1Institute of Preclinical Medicine, Norman Bethune University of Medical Sciences, Changchun.
Objective:
To observe the ameliorative effect of Jishentang (JST) on renal lesions in experimental diabetic rats.
Methods:
The diabetic rats were randomly divided into three groups: group with out treatment, group with enalapril treatment (the dose of enalapril was 1 mg/kg.d) and group with JST treatment (the dose of JST was 22.4 g/kg.d). The treatment lasted for 8 weeks.
Results:
(1) JST treatment attenuated the renal hypertrophy and ratio of kidney and body weight (P < 0.01). (2) JST treatment reduced the levels of SCr and BUN and the levels of Alb, beta 2-m and the activity of NAG in urine in diabetic rats significantly (P < 0.01). The levels of TG and TCh decreased and the levels of HDL-C increased in the serum of the JST treated diabetic rats (P < 0.01). (3) The glomerular basement membrane thickening and volume density of PAS positive staining in mesangial area were significantly decreased in JST treated diabetic rats.
Conclusions:
JST exerted obvious ameliorative effect on renal function and structure in diabetic rats.