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[Protection mechanism of huanshaodan decoction in the brain]
Abstract
Objective:
To observe the protective effect of Huanshaodan (HSD) in mouse brain in a steady ischemia-reperfusion model.
Methods:
Step-through experiment, receptor binding test and choline acetyl-transferase (CAT) activity determination was performed.
Results:
After HSD treatment, mice made much less mistakes in step-through experiment than sham groups. Meanwhile the 3H-MK801 binding of cerebral cortex and hippocampus tissues was significantly decreased. CAT activity of cerebral cortex and hippocampus tissue were increased respectively.
Conclusion:
HSD might antagonize ischemia injury of brain through modulating excessive activation of glutamate N-methyl-D-Aspartic acid receptors.