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Related Experiment Videos

Dehydroepiandrosterone replacement in aging humans.

M A Flynn1, D Weaver-Osterholtz, K L Sharpe-Timms

  • 1Department of Family Medicine, University of Missouri School of Medicine, Columbia 65212, USA.

The Journal of Clinical Endocrinology and Metabolism
|May 14, 1999
PubMed
Summary
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This study found that dehydroepiandrosterone (DHEA) replacement therapy in healthy older men caused mild, temporary changes in blood values but no improvements in body composition, urological, or psychological measures.

Area of Science:

  • Endocrinology
  • Gerontology
  • Pharmacology

Background:

  • Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) have garnered significant attention for alleged health benefits.
  • Objective evaluation of DHEA replacement therapy is crucial, particularly in aging populations.

Purpose of the Study:

  • To assess the effects of DHEA replacement therapy in healthy older men.
  • To objectively evaluate changes in body composition, blood parameters, and psychological well-being.

Main Methods:

  • A 9-month, double-blind, cross-over, randomized study involving 39 healthy older men.
  • Participants received replacement doses of DHEA (100 mg) or placebo for 3-month periods.
  • Measurements included lean body mass, hematology, chemistry, endocrine values, urological, and psychological data.

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Main Results:

  • Mild and temporary significant changes in blood urea nitrogen, creatinine, uric acid, alanine transaminase, cholesterol, HDL, and potassium were observed during DHEA treatment.
  • No significant changes in body composition or urological parameters were detected.
  • All altered blood values returned to baseline after DHEA cessation.

Conclusions:

  • DHEA replacement therapy in healthy older men did not yield significant improvements in body composition, urological function, or psychological well-being.
  • Reported benefits like enhanced sense of well-being or sexual function were not substantiated in this study.
  • The observed blood value alterations were transient and reversible.