Drug treatment of hypertension in older persons in an academic hospital-based geriatrics practice

G Mendelson1, J Ness, W S Aronow

  • 1Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York, USA.

Insights

Hypertension affects 58% of older adults. Treatment goals of <140/90 mm Hg were met in 70% of patients, with specific drug use varying by prior myocardial infarction or congestive heart failure.

Area of Science:

  • Geriatrics
  • Cardiology
  • Public Health

Background:

  • Hypertension is a prevalent condition in older adults.
  • Effective management is crucial for preventing cardiovascular complications.

Purpose of the Study:

  • To determine the prevalence of hypertension in older individuals.
  • To analyze the utilization of antihypertensive medications, including in patients with prior myocardial infarction (MI) or congestive heart failure (CHF).
  • To assess the rate of achieving blood pressure control to <140/90 mm Hg.

Main Methods:

  • Retrospective chart analysis of 1819 older patients (mean age 80 years) from an academic, hospital-based geriatrics practice.
  • Data collected from December 1997 to August 1998.
  • Prevalence of hypertension, drug usage patterns, and blood pressure control were examined.

Main Results:

  • Hypertension was identified in 58% (1051/1819) of the study population.
  • Among hypertensive patients, 70% achieved a blood pressure <140/90 mm Hg.
  • Specific drug prevalences included diuretics (49%), ACE inhibitors (42%), and beta-blockers (28%).
  • In patients with prior MI, beta-blockers (59%) and ACE inhibitors (48%) were common.
  • In patients with CHF, diuretics (100%) and ACE inhibitors (91%) were highly prevalent.

Conclusions:

  • The study confirms a high prevalence of hypertension in older adults within an academic geriatric practice.
  • Educational interventions appear to have influenced prescribing patterns, increasing the use of diuretics and beta-blockers.
  • A significant majority (70%) of hypertensive older patients achieved target blood pressure control.
Abstract

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.