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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

587
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
587
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Confounding in Epidemiological Studies01:27

Confounding in Epidemiological Studies

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Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Esophagus01:24

Esophagus

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The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
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Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

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Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Oncology And Carcinogenesis Not Elsewhere Classified
  11. No Association Between Colon Cancer And Adenocarcinoma Of The Oesophagus In A Population Based Cohort Study In Sweden.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Oncology And Carcinogenesis Not Elsewhere Classified
  11. No Association Between Colon Cancer And Adenocarcinoma Of The Oesophagus In A Population Based Cohort Study In Sweden.

Related Experiment Videos

No association between colon cancer and adenocarcinoma of the oesophagus in a population based cohort study in Sweden.

J Lagergren1, O Nyren

  • 1Department of Medical Epidemiology, Karolinska Institute, Box 281, S-171 77 Stockholm, Sweden.

Gut
|May 14, 1999

View abstract on PubMed

Summary
This summary is machine-generated.

This study found no evidence linking colon cancer to oesophageal adenocarcinoma. Further research into common causes or genetic defects for these cancers is likely not warranted.

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Previous studies suggested a link between oesophageal and colonic neoplasia, but findings were inconsistent.
  • Such an association would imply shared underlying causes for these cancers.

Purpose of the Study:

  • To investigate a potential association between oesophageal adenocarcinoma and colonic neoplasia.
  • To determine if patients with colon cancer have an increased risk of developing oesophageal adenocarcinoma.

Main Methods:

  • A population-based retrospective cohort study of Swedish patients diagnosed with colon cancer between 1958 and 1992.
  • Reviewed 538,500 person-years at risk among 118,030 patients.
  • Used standardized incidence ratios (SIR) to compare observed versus expected oesophageal adenocarcinoma cases.

Main Results:

  • Eleven cases of oesophageal adenocarcinoma were observed, compared to 9.5 expected (SIR=1.2, 95% CI 0.6-2.1).
  • No increasing or decreasing risk trend was observed over time after colon cancer diagnosis.
  • No significant sex differences in relative risk were found.

Conclusions:

  • The study results do not support a common link between colon cancer and oesophageal adenocarcinoma.
  • Investigating shared etiological factors or genetic defects may not be productive.
  • Routine screening for colonic neoplasia in oesophageal cancer patients, or vice versa, is not recommended.