Histomorphological and ultrastructural studies of a rat myocardium in experimental conditions

A histomorphological and ultrastructural analysis of the adaptation reaction of the rat heart muscle during an early experimental alloxan diabetes has been carried out. Changes were observed in the orthomorphology of the ultrastructure which appeared as vesicular intercalated discs within the fasciae adherentes regions, as changes in the mitochondria, cell nucleus, myofibrills and in the sarcoplasmic reticulum with a simultaneous increase in the number of lipid bodies. The described alterations are dependent on the duration time of the experiment and on the disturbances in the entire and local system cellular metabolism.