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Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Organoid nevus.

H Pinkus

    Modern Problems in Paediatrics
    |October 20, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Organoid nevus is a skin malformation that can develop tumors and may be linked to other abnormalities. Early surgical excision before adolescence is recommended for this condition.

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    Area of Science:

    • Dermatology
    • Pathology
    • Genetics

    Background:

    • Organoid nevus is a congenital skin malformation involving multiple skin appendages.
    • It commonly presents on the scalp and exhibits predictable developmental changes.
    • Associated syndromes, such as Schimmelpenning-Feuerstein-Mims syndrome, involve neurological and skeletal abnormalities.

    Purpose of the Study:

    • To describe the clinical and histological characteristics of organoid nevus.
    • To highlight the potential for secondary tumor development.
    • To emphasize the recommended treatment approach.

    Main Methods:

    • Review of clinical and histological data of organoid nevus cases.
    • Analysis of associated syndromes and their manifestations.
    • Evaluation of treatment outcomes.

    Main Results:

    • Organoid nevus presents in various forms, with nevus sebaceus and nevus verrucosus being most common.
    • A significant percentage of cases are prone to secondary benign or semimalignant adnexal tumors.
    • Association with neurological and skeletal abnormalities in organoid nevus syndrome is noted.

    Conclusions:

    • Organoid nevus requires careful monitoring due to potential complications.
    • Early total excision before adolescence is the optimal treatment strategy.
    • Understanding associated syndromes is crucial for comprehensive patient management.