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A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
Published on: December 16, 2022
Bone marrow as a potential source of hepatic oval cells
B E Petersen1, W C Bowen, K D Patrene
1Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. bryon+@pitt.edu
Science (New York, N.Y.)
|May 15, 1999
Summary
Bone marrow stem cells can generate liver cells, including hepatocytes and biliary cells, during liver regeneration. This finding reveals a novel epithelial cell lineage capability for bone marrow stem cells.
Area of Science:
- Hepatology
- Stem Cell Biology
- Regenerative Medicine
Background:
- Bone marrow stem cells are known to differentiate into hematopoietic and mesenchymal lineages.
- Their role in liver regeneration, specifically in producing hepatocytes, biliary cells, or oval cells, was previously unknown.
Purpose of the Study:
- To investigate the potential of bone marrow stem cells to contribute to liver regeneration.
- To determine if bone marrow stem cells possess epithelial cell lineage capabilities.
Main Methods:
- Cross-sex and cross-strain bone marrow and liver transplantation models in rats.
- Chemical treatments (2-acetylaminofluorene and hepatic injury) to induce oval cell proliferation.
- Utilized Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen markers to trace donor-derived liver cells.
Main Results:
- A proportion of the regenerated hepatic cells in transplanted rats were confirmed to be of bone marrow origin.
- Demonstrated successful differentiation of bone marrow-derived cells into hepatic cell types.
Conclusions:
- Bone marrow stem cells have the capacity to differentiate into epithelial liver cells.
- This study identifies a novel role for bone marrow stem cells in liver regeneration and epithelial lineage development.
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