[Interactions between selenium and cadmium on lipid peroxidation of encephalon in mice]

70 Kunming male mice were randomly divided into five groups. Three groups were injected intraperitoneally with selenium (Se) on the dosages of 0.00, 0.05 and 0.10 mg/kg body weight and other two groups were treated with 0.23 mg/kg cadmium (Cd) and 0.10 mg/kg Se plus 0.23 mg/kg Cd, for 50 days. The concentrations of glutathione (GSH) and malonic dialdehyde (MDA) of cerebellum, pons, corpora quadrigemina, thalamus and pallium were detected respectively. The results showed that the GSH concentrations in these tissues decreased in all exposed groups. Cd increased the MDA level significantly in pons, corpora quadrigemina and thalamus, and Se could antagonize the harmful effect induced by Cd. But Se itself could also decrease the GSH level of encephalon.