[The free radicals and nickel carcinogenesis]

The relationship between free radicals and the carcinogenesis of nickel and its compounds was summarized. Ni(II) could enhance the production of free radicals mainly in three pathways: Fenton reaction, enhancing lipid peroxidation and decreasing cellular antioxidantive defense system. Thus free radacals lead cell carcinogenesis. It suggested that the carcinogenesis of Ni(II) was mainly related to the effect of free radicals.