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Published on: April 7, 2015
Intrapericardial streptokinase in purulent pericarditis
R Juneja1, S S Kothari, A Saxena
1Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India. rjuneja@medinst.ernet.in
Archives of Disease in Childhood
|May 18, 1999
Summary
Pericardial irrigation using streptokinase effectively cleared purulent pericarditis in most children. This treatment demonstrated rapid pus clearance with no long-term constriction observed in follow-up.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
Background:
- Purulent pericarditis is a serious condition in children.
- Effective drainage and clearance of pericardial pus are crucial for patient outcomes.
Purpose of the Study:
- To evaluate the efficacy and safety of pericardial irrigation with streptokinase in children with purulent pericarditis.
Main Methods:
- Six children with confirmed purulent pericarditis were treated.
- Pericardial irrigation was performed using streptokinase.
- Drainage of purulent fluid and monitoring for complications were conducted.
Main Results:
- A mean of 861 ml of purulent fluid was drained.
- Five out of six children achieved complete pus clearance within 3-8 days.
- One child experienced intrapericardial hemorrhage and required surgical intervention.
Conclusions:
- Streptokinase pericardial irrigation is a viable treatment for purulent pericarditis in children.
- The procedure showed rapid pus clearance with a low rate of serious complications.
- No cases of pericardial constriction were noted during long-term follow-up.
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