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Drug resistance in malaria.

N J White1

  • 1Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

British Medical Bulletin
|May 18, 1999
PubMed
Summary

Drug resistance in malaria parasites is a growing global problem, complicating treatment options. This review examines resistance mechanisms and treatment strategies for Plasmodium falciparum and P. vivax.

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Area of Science:

  • * Infectious Diseases
  • * Tropical Medicine
  • * Pharmacology

Background:

  • * Widespread antimalarial drug resistance poses a significant threat to global malaria control efforts.
  • * Emerging resistance in Plasmodium falciparum and Plasmodium vivax necessitates updated treatment guidelines.

Purpose of the Study:

  • * To review current knowledge on antimalarial drug resistance mechanisms.
  • * To assess the prevalence and extent of resistance in key malaria parasites.
  • * To provide evidence-based recommendations for malaria treatment in resistant areas.

Main Methods:

  • * Comprehensive literature review of published studies on antimalarial drug resistance.
  • * Analysis of data on resistance patterns for Plasmodium falciparum and Plasmodium vivax.
  • * Synthesis of current treatment guidelines and expert recommendations.

Main Results:

  • * Significant geographic variation in drug resistance patterns observed globally.
  • * Specific mechanisms of resistance identified for various antimalarial drug classes.
  • * Increasing resistance necessitates a shift towards combination therapies and novel treatment approaches.

Conclusions:

  • * Antimalarial drug resistance is a complex and evolving challenge requiring ongoing surveillance.
  • * Effective malaria treatment relies on understanding local resistance profiles and implementing appropriate therapeutic strategies.
  • * Continued research and development of new antimalarials are crucial for sustained malaria elimination.

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