Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High bone turnover in the elderly.

R Theiler1, H B Stähelin, M Kränzlin

  • 1Department of Rheumatology, University Hospital, Basel, Switzerland.

Archives of Physical Medicine and Rehabilitation
|May 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Playing a musical instrument is associated with slower cognitive decline in community-dwelling older adults.

Aging clinical and experimental research·2020
Same author

Relationship between bone mineral content and bone turnover markers, sex hormones and calciotropic hormones in pre- and early pubertal children.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Influence of fall environment and fall direction on risk of injury among pre-frail and frail adults.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Physical performance among patients aged 70 + in acute care: a preliminar comparison between the Short Physical Performance Battery and the De Morton Mobility Index with regard to sensitivity to change and prediction of discharge destination.

Aging clinical and experimental research·2019
Same author

Timeline of functional recovery after hip fracture in seniors aged 65 and older: a prospective observational analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2019

Physical inactivity in older adults significantly increases bone resorption markers, suggesting low mechanical loading, not hyperparathyroidism, drives high bone turnover. This impacts bone health in the elderly.

Area of Science:

  • Gerontology
  • Bone Metabolism
  • Biochemistry

Background:

  • Bone metabolism undergoes significant changes with aging.
  • Lifestyle factors, including physical activity and vitamin D levels, are crucial for maintaining bone health in the elderly.

Purpose of the Study:

  • To investigate the relationship between lifestyle factors and biochemical markers of bone metabolism in advanced age.
  • To differentiate the impact of physical activity and vitamin D status on bone turnover in elderly populations.

Main Methods:

  • Cross-sectional study involving 312 ambulatory and 193 institutionalized individuals aged 54-99.
  • Assessed urinary bone resorption markers (deoxypyridinolin, N-telopeptides), vitamin D metabolites, and intact parathyroid hormone (iPTH).
  • Correlated biochemical markers with a six-grade physical activity score, differentiating between ambulatory and institutionalized settings.

Related Experiment Videos

Main Results:

  • Higher bone resorption markers were observed in institutionalized and physically inactive individuals compared to ambulatory and active ones.
  • Vitamin D deficiency was prevalent, especially in institutionalized subjects (86%), with lower 1,25-dihydroxyvitamin D levels.
  • Serum iPTH concentrations were similar between institutionalized and ambulatory groups, despite vitamin D differences.

Conclusions:

  • Physical inactivity and associated low mechanical loading, rather than secondary hyperparathyroidism, appear to be primary drivers of elevated bone turnover in the elderly.
  • Lifestyle modifications, particularly promoting physical activity, are essential for managing bone metabolism in aging populations.
  • Biochemical markers of bone resorption are sensitive indicators of physical activity levels in older adults.