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Related Experiment Videos

Phenelzine-induced sexual dysfunction treated with sildenafil.

S Gupta1, P Masand, A K Ashton

  • 1State University of New York Health Science Center, Syracuse, New York, USA.

Journal of Sex & Marital Therapy
|May 18, 1999
PubMed
Summary

Phenelzine (Nardil) can cause sexual dysfunction in men, but sildenafil (Viagra) effectively treats this side effect. This case study highlights a successful treatment for antidepressant-induced sexual issues.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Sexual Medicine

Background:

  • Phenelzine (Nardil) is a monoamine oxidase inhibitor (MAOI) used to treat depression.
  • Sexual dysfunction is a known potential side effect of antidepressant medications, including MAOIs.
  • The Arizona Sexual Experiences Scale for males (ASEX-Male) is a validated tool for assessing male sexual dysfunction.

Observation:

  • A 56-year-old male patient experienced sexual dysfunction.
  • The sexual dysfunction was temporally associated with the initiation of phenelzine treatment.
  • The patient's sexual function was evaluated using the ASEX-Male scale.

Findings:

  • Sildenafil (Viagra) was administered to address the sexual dysfunction.
  • The patient showed a successful resolution of sexual dysfunction following sildenafil treatment.

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  • The ASEX-Male scale scores indicated significant improvement in sexual function.

    • Implications:

    • Sildenafil is a viable treatment option for phenelzine-induced sexual dysfunction.
    • Clinicians should be aware of and screen for sexual side effects associated with phenelzine.
    • Further research may explore the efficacy of phosphodiesterase type 5 inhibitors for other antidepressant-induced sexual dysfunctions.