Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Panic disorder subtypes: differential responses to CO2 challenge.

B Biber1, T Alkin

  • 1Department of Psychiatry, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

The American Journal of Psychiatry
|May 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new concept affecting restoration of inflammation-reactive astrocytes.

Neuroscience·2013
Same author

Naloxone in ultralow concentration restores endomorphin-1-evoked Ca²⁺ signaling in lipopolysaccharide pretreated astrocytes.

Neuroscience·2012
Same author

Ischaemic pre-conditioning means an increased adenosine metabolism with decreased glycolytic flow in ischaemic pig myocardium.

Acta anaesthesiologica Scandinavica·2010
Same author

Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: an experimental study in the pig.

Acta physiologica (Oxford, England)·2009
Same author

High intrathecal bupivacaine for severe pain in the head and neck.

Acta anaesthesiologica Scandinavica·2009
Same author

Metabolic responses in ischemic myocardium after inhalation of carbon monoxide.

Acta anaesthesiologica Scandinavica·2009

Patients with a respiratory subtype of panic disorder showed greater sensitivity to carbon dioxide (CO2) challenges compared to non-respiratory subtypes. This suggests CO2 hypersensitivity may be linked to specific panic disorder presentations.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pulmonology

Background:

  • Panic disorder is a heterogeneous condition with varying symptom presentations.
  • Subtyping panic disorder may aid in understanding its underlying pathophysiology.
  • Respiratory symptoms are common in panic disorder, but their specific role is not fully understood.

Purpose of the Study:

  • To investigate differential sensitivity to carbon dioxide (CO2) in panic disorder subtypes.
  • To explore the relationship between prominent respiratory symptoms and CO2 sensitivity in panic disorder patients.

Main Methods:

  • A CO2 challenge test using a 35% CO2 and 65% O2 mixture was administered.
  • Fifty-one unmedicated patients with DSM-III-R panic disorder were divided into respiratory (N=28) and non-respiratory (N=23) subtypes.

Related Experiment Videos

  • Comparison of physiological, psychological, pulmonary function, panic rates, and smoking habits between subtypes.

    • Main Results:

    • The respiratory subtype group exhibited significantly higher sensitivity to CO2 compared to the non-respiratory group.
    • Respiratory subtype patients reported higher Panic and Agoraphobia Scale scores and longer illness duration, indicating greater illness severity.
    • Increased cigarette consumption in the respiratory group may contribute to illness severity and panic disorder pathogenesis.

    Conclusions:

    • The CO2 challenge serves as a valuable tool for differentiating panic disorder subtypes.
    • A specific association may exist between the prominent respiratory symptom subtype of panic disorder and CO2 hypersensitivity.