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A new anti-tubulin agent containing the benzo[b]thiophene ring system
K G Pinney1, A D Bounds, K M Dingeman
1Department of Chemistry, Baylor University, Waco, TX 76798-7348, USA.
Bioorganic & Medicinal Chemistry Letters
|May 18, 1999
Abstract:
A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6-methoxybe nzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.