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Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a
A Al-Omar1, S Abdou, L De Robertis
1Unité Mixte de Recherche CNRS-Université, Structure et Réactivité des Systèmes Moléculaires Complexes, Université Henri-Poincaré, Nancy-1, and Faculté des Sciences Pharmaceutiques et Biologiques 5.
Abstract:
Ability of molecular complexes of [Doxorubicin (DX)-cyclodextrin (Cd)] to enhance the anticellular activity of antineoplastic drug Doxorubicin and to reverse its multidrug resistance has been investigated. A spectroscopic study of the alpha, beta, and gamma-[DX-Cds] complexes has been investigated in relation to their biological effects on a multidrug resistant (MDR) human rectal adenocarcinoma cell line (HRT-18). A ten fold enhancement of DX anticellular activity in presence of beta-cyclodextrin alone was detected.