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Updated: Aug 5, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing
G Wang1, E Gunic, J L Girardet
1Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, California 92626, USA.
Abstract:
A conformationally locked, 2',4'-C-bridged 2'-deoxyribofuranoside2 was condensed with silylated pyrimidines to give 2',4'-C-bridged bicyclonucleosides, which were converted to the phosphoramidites and incorporated into oligodeoxynucleotides (ODNs). The hybridization data of the modified ODNs to DNA and RNA are presented.
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