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New synthetic heparin mimetics able to inhibit thrombin and factor Xa
M Petitou1, P Duchaussoy, P A Driguez
1Sanofi Recherche, Haemobiology Research Department, Toulouse, France.
Bioorganic & Medicinal Chemistry Letters
|May 18, 1999
Abstract:
Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT III) binding pentasaccharide prolonged at the non-reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.