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Synthetic oligosaccharides having various functional domains: potent and potentially safe heparin mimetics
M Petitou1, P A Driguez, P Duchaussoy
1Sanofi Recherche, Haemobiology Research Department, Toulouse, France.
Bioorganic & Medicinal Chemistry Letters
|May 18, 1999
Abstract:
A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.