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New photoaffinity analogs of paclitaxel
I Ojima1, P Y Bounaud, D G Ahern
1Department of Chemistry, State University of New York at Stony Brook, 11794-3400, USA.
Bioorganic & Medicinal Chemistry Letters
|May 18, 1999
Abstract:
Two new photoreactive paclitaxel analogs bearing [3H2]-3-(4-benzoyl)phenylpropanoyl group as the photophore as well as radiolabeling unit at the 7 and 10 positions, respectively, are developed. These new photoreactive analogs showed excellent preliminary results on the photoaffinity labeling of tubulin and P-glycoprotein.