New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

Nevirapine hypersensitivity.

Handbook of experimental pharmacology·2009

Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.

Chemico-biological interactions·2002

Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system.

Current drug metabolism·2002

Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm.

Toxicology·2001

Is it possible to more accurately predict which drug candidates will cause idiosyncratic drug reactions?

Current drug metabolism·2001

Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity.

Chemical research in toxicology·2001

Engineered PS and PAN Microplastic Fibers Elicit Stronger A549 Epithelial Responses than Spherical Polystyrene Particles.

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Design, Synthesis, and Evaluation of Alkoxyamine Anticancer Prodrugs Bearing Galactoside as an Enzyme-Activated Trigger.

Chemical research in toxicology·2026

Differential Mutagenic Response of Rat Liver and Lung to Nicotine-Derived Nitrosamine Ketone (NNK).

Chemical research in toxicology·2026

Cellular Uptake, Intracellular Fate, and Cytotoxicity of Micro- and Nanoparticulate Nickel Substances in Human Lung Cells.

Chemical research in toxicology·2026

The Dual Role of DNA Cross-linking Agents: From Genotoxicity to cGAS-STING-Mediated Immune Activation.

Chemical research in toxicology·2026

High-Resolution Mass Spectrometric Analysis of Selected DNA Adducts in Smokeless Tobacco Users' Oral Cells.

Chemical research in toxicology·2026

HSV-1 induces stable associations between the Golgi and endosomes within the cytoplasmic viral assembly compartment of neuronal cells.

Journal of virology·2026

Targeting CLK1 by CRISPR tools and pharmacological inhibition modulates the innate immune response and dengue virus replication.

The Biochemical journal·2026

Changing Burden of Opportunistic Infections in the New ART Era.

Recent advances in anti-infective drug discovery·2026

Alveolar macrophage heterogeneity in pulmonary hypertension: pathogenic mechanisms and precision intervention.

Journal of hypertension·2026

Pulmonary ILC2 Priming as a Link Between Severe Early-Life RSV Bronchiolitis and Asthma.

American journal of respiratory cell and molecular biology·2026

Anemoside B4 from Pulsatilla chinensis Ameliorates Ulcerative Colitis by Inhibiting Inflammatory Responses via the Modulation of the Gut Microbiota-Immune Interplay.

The American journal of Chinese medicine·2026

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New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

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Nevirapine hypersensitivity.

Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.

Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system.

Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm.

Is it possible to more accurately predict which drug candidates will cause idiosyncratic drug reactions?

Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity.

Engineered PS and PAN Microplastic Fibers Elicit Stronger A549 Epithelial Responses than Spherical Polystyrene Particles.

Design, Synthesis, and Evaluation of Alkoxyamine Anticancer Prodrugs Bearing Galactoside as an Enzyme-Activated Trigger.

Differential Mutagenic Response of Rat Liver and Lung to Nicotine-Derived Nitrosamine Ketone (NNK).

Cellular Uptake, Intracellular Fate, and Cytotoxicity of Micro- and Nanoparticulate Nickel Substances in Human Lung Cells.

The Dual Role of DNA Cross-linking Agents: From Genotoxicity to cGAS-STING-Mediated Immune Activation.

High-Resolution Mass Spectrometric Analysis of Selected DNA Adducts in Smokeless Tobacco Users' Oral Cells.

HSV-1 induces stable associations between the Golgi and endosomes within the cytoplasmic viral assembly compartment of neuronal cells.

Targeting CLK1 by CRISPR tools and pharmacological inhibition modulates the innate immune response and dengue virus replication.

Changing Burden of Opportunistic Infections in the New ART Era.

Alveolar macrophage heterogeneity in pulmonary hypertension: pathogenic mechanisms and precision intervention.

Pulmonary ILC2 Priming as a Link Between Severe Early-Life RSV Bronchiolitis and Asthma.

Anemoside B4 from Pulsatilla chinensis Ameliorates Ulcerative Colitis by Inhibiting Inflammatory Responses via the Modulation of the Gut Microbiota-Immune Interplay.

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New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

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