Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shear stress distribution in arterial tree models, generated by constrained constructive optimization.

W Schreiner1, F Neumann, R Karch

  • 1Department of Medical Computer Sciences, University of Vienna, Spitalgasse 23, A-1090 Vienna, Austria. wolfgang.schreiner@akh-wien.ac.at

Journal of Theoretical Biology
|May 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-BCMA CAR T administration in a relapsed and refractory multiple myeloma patient after COVID-19 infection: a case report.

Journal of medical case reports·2021
Same author

Neural correlates of script-driven imagery in adolescents with interpersonal traumatic experiences: A pilot study.

Psychiatry research. Neuroimaging·2020
Same author

Smartphone-based clinical diagnostics: towards democratization of evidence-based health care.

Journal of internal medicine·2018
Same author

An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia.

Leukemia·2017
Same author

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome.

Leukemia·2017
Same author

The effect of a new antiandrogenic steroid, 6-chloro-17-HYDROXY-1α, 2α-methylenepregna-4,6-diene-3,20-dione acetate (cyproterone acetate) on the sebaceous glands of mice.

The Journal of investigative dermatology·2015
Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
See all related articles

Constrained Constructive Optimization (CCO) models arterial trees to optimize blood flow. Rescaling these models can alter shear stress distribution, with intravascular volume optimization minimizing variability.

Area of Science:

  • Cardiovascular physiology
  • Biomedical engineering
  • Computational fluid dynamics

Background:

  • Arterial tree models are crucial for understanding blood flow dynamics.
  • Existing models often simplify vessel geometry and flow conditions.
  • Optimizing arterial models requires balancing structural efficiency with physiological constraints.

Purpose of the Study:

  • To develop and analyze arterial tree models using Constrained Constructive Optimization (CCO).
  • To investigate methods for rescaling CCO-generated arterial trees to achieve desired shear rate and viscosity profiles.
  • To evaluate the impact of optimization targets and bifurcation laws on shear stress distribution.

Main Methods:

  • Generation of arterial tree models using the Constrained Constructive Optimization (CCO) algorithm.

Related Experiment Videos

  • Implementation of a bifurcation law relating parent and daughter vessel radii.
  • Development of methods for rescaling CCO trees to target specific root shear rates and variable blood viscosity.
  • Analysis of shear stress and its variability across different vessel segments and bifurcations.

    • Main Results:

    • CCO models create optimized arterial trees with consistent flow and pressure at terminal sites.
    • Rescaling methods allow adjustment of shear rate and viscosity profiles without altering overall geometry.
    • Shear stress and its variability are typically higher in smaller arterial segments.
    • Optimization for intravascular volume minimizes shear stress variability within bifurcations.
    • Rank analysis reveals consistent shear stress patterns at bifurcations, with parent segments having medium shear stress.

    Conclusions:

    • CCO provides a robust framework for generating realistic arterial tree models.
    • The presented rescaling techniques offer control over hemodynamic parameters like shear stress and viscosity.
    • Model optimization targets significantly influence shear stress distribution, highlighting the importance of selecting appropriate objectives.
    • Understanding shear stress patterns in arterial bifurcations is key to predicting vascular health and disease.