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Related Experiment Videos

Asymmetric adiabatic pulses for NH selection.

T L Hwang1, P C van Zijl, M Garwood

  • 1Department of Radiology and Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 18, 1999
PubMed
Summary

This study introduces a novel asymmetric adiabatic full passage for NMR spectroscopy. This method creates a sharper inversion band, improving the selection of specific molecular groups in complex experiments.

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Pulse Sequence Design
  • Biophysical Chemistry

Background:

  • NMR experiments often require frequency-selective pulses for precise magnetization inversion.
  • Sharply demarcating one side of an inversion band is crucial for specific NMR applications.
  • Asymmetric adiabatic full passages offer potential for narrower transition bandwidths.

Purpose of the Study:

  • To develop a highly efficient asymmetric adiabatic full passage for NMR.
  • To achieve a narrower transition bandwidth on one side of the inversion band.
  • To apply these pulses in water-flip-back HSQC experiments.

Main Methods:

  • Combining two adiabatic half passages with different modulation functions (HS12 and tanh/tan).

Related Experiment Videos

  • Utilizing asymmetric pulse durations for each half passage.
  • Implementing the asymmetric pulses in water-flip-back HSQC with a double spin echo reverse INEPT step.

    • Main Results:

    • The asymmetric pulse created a transition band approximately 2.5 times narrower than a symmetric hyperbolic secant pulse.
    • HS12 provided a sharp inversion transition on one side.
    • tanh/tan achieved broadband inversion on the other side.

    Conclusions:

    • The developed asymmetric adiabatic full passage is highly efficient for NMR.
    • This method enables precise selection of NH groups adjacent to water signals.
    • The technique enhances the utility of water-flip-back HSQC experiments.