Related Experiment Video
Updated: Aug 26, 2026

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
Published on: December 12, 2014
On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological
M E DeVries1, L Ran, D J Kelvin
1Laboratory of Molecular Inflammation and Immunology, Robarts Research Institute, and the Department of Microbiology and Immunology, University of Western Ontario, London Ontario, N6G 2V4, Canada.
Abstract:
Most, if not all, chemokines bind to seven transmembrane spanning G protein-coupled receptors and activate cellular migration. Stimulated chemokine expression is essential for directing leukocyte emigration from the circulation into sites of inflammation and tissue damage. In contrast, constitutive chemokine expression plays a role in the development of lymphoid cells, organs, and tissues. The present review examines rheumatoid arthritis and transplantation rejection as two examples of pathological conditions where chemokine directed leukocyte infiltration aids in the pathogenesis of the disease. We further discuss insights into leukocyte trafficking gained by chemokine and chemokine receptor transgenic and null mutant mice.
More Related Videos
Related Concept Videos
Inflammation
Inflammatory Response I: Vascular and Cellular
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation: Introduction
Acute Inflammation I: Inflammatory Response
Chronic Inflammation: Introduction

