Time to onset of effect of fluticasone propionate in patients with asthma
Summary
This summary is machine-generated.Inhaled fluticasone propionate (FP) provides rapid asthma symptom relief within 1 day and improves lung function within 1 week. Maximal benefits for lung function and symptom scores are observed within 2-3 weeks of starting FP treatment.
Area Of Science
- Pulmonology
- Pharmacology
- Clinical Medicine
Background
- Inhaled glucocorticoids are effective asthma treatments.
- The onset and maximal effect timelines for these agents are not well-established.
Purpose Of The Study
- To determine the onset and maximal effect times of inhaled fluticasone propionate (FP) in asthma patients.
Main Methods
- Analysis of 8 randomized, double-blind, placebo-controlled trials (duration ≥ 8 weeks).
- 1461 corticosteroid-naive patients received FP (25-500 mcg) or placebo BID.
- Efficacy assessed via PEF, symptom scores, albuterol use, and FEV1.
Main Results
- Significant improvements in PEF, symptoms, and albuterol use seen by Day 1 (P <.001).
- Significant FEV1 increases observed by Week 1 (P <.001).
- Maximal effects for PEF/FEV1 within 3 weeks; symptom/albuterol use within 2 weeks.
Conclusions
- FP offers rapid onset of benefits for PEF, symptoms, and albuterol use within 1 day.
- FEV1 improved within 1 week; maximal effects seen within 3 weeks.
- Time to response was not influenced by sex, age, or FP dose.
View abstract on PubMed