A novel wheat gliadin as a cause of exercise-induced anaphylaxis
Summary
This summary is machine-generated.Wheat-dependent, exercise-induced anaphylaxis is a severe allergic reaction. A novel gamma-like gliadin identified as the major allergen, with a gluten-free diet recommended for treatment.
Area Of Science
- Allergology
- Immunology
- Gastroenterology
Background
- Food-dependent, exercise-induced anaphylaxis is a severe allergic reaction triggered by specific foods consumed before exercise.
- This condition often goes undiagnosed as neither the food nor exercise alone causes symptoms.
Purpose Of The Study
- To identify allergens in wheat-dependent, exercise-induced anaphylaxis.
- To describe the clinical outcomes in 18 adult patients.
Main Methods
- Wheat allergens were detected using immunoblotting and purified.
- IgE-binding and in vivo reactivity were assessed via ELISA and skin prick testing.
- Patients' clinical histories and responses to a wheat-free diet were documented.
Main Results
- A novel 65-kd gamma-like gliadin and a 40-kd alpha-gliadin were identified as allergens.
- All 18 patients had IgE antibodies to the novel gamma-like gliadin; 15 showed positive skin prick test responses.
- A wheat-free diet led to symptom resolution in most patients, though some reacted to accidental wheat ingestion.
Conclusions
- Wheat is a common trigger for food-dependent, exercise-induced anaphylaxis, with a novel gamma-like gliadin as the primary allergen.
- Skin prick testing with crude gliadin is recommended for diagnosis.
- A gluten-free diet is the recommended treatment for this potentially life-threatening allergy.
View abstract on PubMed