Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preleukemic syndromes.

R V Pierre

    Virchows Archiv. B, Cell Pathology
    |November 17, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Cytogenetic abnormalities can help identify preleukemic states, a challenging diagnosis. Patients with these abnormalities are more likely to progress to acute nonlymphocytic leukemia (ANLL).

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Getting better all the time.

    CAP today·2001
    Same author

    Left shift and inflammation: a never-ending story.

    American journal of clinical pathology·1998
    Same author

    Myelodysplastic syndrome treatment with danazol and cis-retinoic acid.

    American journal of hematology·1995
    Same author

    Incremental value of the leukocyte differential and the rapid creatine kinase-MB isoenzyme for the early diagnosis of myocardial infarction.

    Annals of internal medicine·1995
    Same author

    Ethylenediamine tetraacetic acid-associated leukoagglutination.

    American journal of clinical pathology·1995
    Same author

    Flow cytometric reticulocyte analysis. Multiinstitutional interlaboratory correlation study.

    American journal of clinical pathology·1994
    Same journal

    Studies on cell surface conformation following injury. I. Scanning and transmission electron microscopy of cell surface changes following p-chloromercuribenzene sulfonic acid (pcmbs)-induced injury of Ehrlich ascites tumor cells.

    Virchows Archiv. B, Cell pathology·1979
    Same journal

    [In vitro interactions between normal liver cells and cancer cells: an ultrastructural study (author's transl)].

    Virchows Archiv. B, Cell pathology·1979
    Same journal

    Cell population kinetics in the mucosal crypts of the descending colon of the mouse.

    Virchows Archiv. B, Cell pathology·1979
    Same journal

    Cell proliferation in epithelium of murine oral mucosa in vivo and in vitro. An autoradiographic study using tritiated thymidine.

    Virchows Archiv. B, Cell pathology·1979
    Same journal

    DNA distribution in biopsy specimens from human cervical carcinoma investigated by flow cytometry.

    Virchows Archiv. B, Cell pathology·1979
    Same journal

    Effects of a single high dose of 55Fe in mice.

    Virchows Archiv. B, Cell pathology·1979
    See all related articles

    Area of Science:

    • Hematology
    • Oncology
    • Cytogenetics

    Background:

    • Acute nonlymphocytic leukemia (ANLL) often has a preclinical, preleukemic phase.
    • Recognizing this preleukemic stage is difficult using conventional morphologic techniques.

    Purpose of the Study:

    • To evaluate the utility of cytogenetic studies in recognizing preleukemic states.
    • To determine the prognostic significance of cytogenetic abnormalities in preleukemia.

    Main Methods:

    • Prospective study of 284 patients with suspected preleukemia.
    • Analysis of cytogenetic abnormalities using banded chromosome studies.

    Main Results:

    • Cytogenetic abnormalities were detected in 30% of patients with suspected preleukemia.

    Related Experiment Videos

  • 53% of patients who progressed to overt ANLL had cytogenetic abnormalities.
  • 13 of 26 patients showed abnormalities in the preleukemic phase.

    • Conclusions:

    • Cytogenetic abnormalities aid in preleukemia recognition but are not specific for early leukemia.
    • The presence of cytogenetic abnormalities indicates a higher likelihood of progression to overt ANLL.