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Updated: Jul 24, 2026
06:44
Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
Published on: April 13, 2018
Venous thromboembolism and cancer
A K Kakkar1, F de Lorenzo, G F Pineo
1Department of Surgery, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Bailliere'S Clinical Haematology
|May 20, 1999
Summary
Cancer-associated thrombosis is common, involving the hemostatic system in tumor progression. Low-molecular-weight heparins show promise for preventing and treating this condition, potentially reducing overall mortality in cancer patients.
Area of Science:
- Oncology
- Hematology
- Thrombosis Research
Background:
- The link between thrombosis and malignant disease is over a century old.
- The hemostatic system plays a role in tumor growth, invasion, and metastasis.
- Coagulation activation is implicated in cancer progression, though mechanisms require further elucidation.
Purpose of the Study:
- To review the involvement of the hemostatic system in cancer.
- To discuss the role of coagulation activation in tumor growth and dissemination.
- To highlight the potential of low-molecular-weight heparins in managing cancer-associated thrombosis.
Main Methods:
- Review of experimental and clinical studies.
- Analysis of laboratory parameters of hemostasis in cancer patients.
- Evaluation of the efficacy and safety of low-molecular-weight heparins.
Main Results:
- Hemostatic system derangements are frequent in cancer patients.
- Overt thrombosis is a common complication, sometimes being the first sign of malignancy.
- Low-molecular-weight heparins have demonstrated safety and efficacy in cancer-associated thrombosis.
Conclusions:
- The hemostatic and fibrinolytic systems are integral to tumor growth and metastasis.
- Low-molecular-weight heparins offer effective prevention and treatment for cancer-associated thrombosis.
- These agents may contribute to reducing overall mortality in cancer patients.
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