Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MIC genes in non-human primates.

P Pellet1, C Vaneensberghe, P Debré

  • 1Laboratoire Central d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpêtrière, Paris, France.

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
|May 20, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing good environmental status through mesozooplankton biodiversity: a step forward.

Journal of plankton research·2024
Same author

Long-term warming and human-induced plankton shifts at a coastal Eastern Mediterranean site.

Scientific reports·2023
Same author

Efficacy of secukinumab and adalimumab in patients with psoriatic arthritis and concomitant moderate-to-severe plaque psoriasis: results from EXCEED, a randomized, double-blind head-to-head monotherapy study.

The British journal of dermatology·2021
Same author

COVID-19 epidemic phases: Criteria, challenges and issues for the future.

Bulletin de l'Academie nationale de medecine·2020
Same author

[Covid-19 epidemic phases: Criteria, challenges and issues for the future].

Bulletin de l'Academie nationale de medecine·2020
Same author

[X<sup>e</sup> International Congress of the Société de pathologie exotique, 8-9 November 2017, Haiphong (Vietnam) - Surgery Access in Tropical Areas].

Bulletin de la Societe de pathologie exotique (1990)·2018

Researchers investigated MIC genes in non-human primates, finding conserved structures essential for function. This suggests functional MIC gene copies exist in primates, similar to humans.

Area of Science:

  • Immunogenetics
  • Molecular Evolution

Background:

  • MIC (MHC class I chain related) genes are part of the immunoglobulin superfamily, located in the MHC region.
  • These genes are recognized by gamma/delta T-cell receptors and exhibit high polymorphism, similar to classical MHC class I genes.
  • Human MIC genes include functional (MIC-A*, MIC-B*) and pseudogenes (MIC-C*, MIC-D*), with pseudogenes often having debilitating mutations.

Purpose of the Study:

  • To sequence segments of MIC genes in seven non-human primate species.
  • To determine the presence of debilitating mutations in primate MIC genes.
  • To assess the evolutionary conservation and potential functionality of MIC genes in non-human primates.

Main Methods:

  • Sequencing of specific segments of MIC genes across seven non-human primate species.

Related Experiment Videos

  • Comparative analysis of primate MIC gene sequences with human counterparts.
  • Identification of conserved residues and potential mutations (e.g., stop codons).

    • Main Results:

    • Primate MIC genes showed high homology to human MIC genes.
    • Key cysteine residues involved in immunoglobulin-like structure maintenance were highly conserved.
    • No stop codons were found in the extracellular or transmembrane segments of the studied primate MIC genes.

    Conclusions:

    • The high conservation of MIC genes in non-human primates suggests functional importance.
    • The absence of debilitating mutations indicates the likely presence of functional MIC gene copies in these species.
    • These findings contribute to understanding the evolution and function of MIC genes within the MHC region.