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Updated: Aug 7, 2026

Methodology for the Efficient Generation of Fluorescently Tagged Vaccinia Virus Proteins
Published on: January 17, 2014
Phylogenetic evidence for recombination in dengue virus
E C Holmes1, M Worobey, A Rambaut
1Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, U.K. Edward.Holmes@zoo.ox.ac.uk
Abstract:
A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.
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