Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytogenetic patterns in acute nonlymphocytic leukemia.

J R Testa, J D Rowley

    Virchows Archiv. B, Cell Pathology
    |November 17, 1978
    PubMed
    Summary

    Chromosomal abnormalities are common in acute nonlymphocytic leukemia (ANLL), with specific translocations like 15;17 highly indicative of acute promyelocytic leukemia. These genetic changes often reappear during relapse, sometimes with further evolution.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    No chromosome arm unturned: in memory of Roland Berger 1934-2012.

    Leukemia·2014
    Same author

    Broadband terahertz pulse emission from ZnGeP2.

    Optics letters·2012
    Same author

    Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression.

    Cancer genetics and cytogenetics·2002
    Same author

    Chromosome translocations: dangerous liaisons revisited.

    Nature reviews. Cancer·2002
    Same author

    The pattern of gene expression in human CD34(+) stem/progenitor cells.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same author

    The pattern of gene expression in mouse Gr-1(+) myeloid progenitor cells.

    Genomics·2001

    Area of Science:

    • Cytogenetics
    • Hematology
    • Oncology

    Background:

    • Acute nonlymphocytic leukemia (ANLL) is characterized by a significant percentage of patients presenting with abnormal karyotypes.
    • Nonrandom chromosomal abnormalities are frequently observed in ANLL, indicating specific genetic drivers.
    • Certain chromosomal alterations are associated with specific subtypes of ANLL, such as acute promyelocytic leukemia.

    Purpose of the Study:

    • To analyze chromosomal banding patterns in patients with ANLL.
    • To identify common and specific nonrandom chromosomal abnormalities in ANLL.
    • To investigate the role of chromosomal abnormalities in disease relapse and evolution.

    Main Methods:

    • Karyotypic analysis of bone marrow cells from ANLL patients.
    • Comparison of chromosomal findings between diagnosis, remission, and relapse.
    • Evaluation of chromosomal changes in ANLL patients with a history of malignant lymphoma treatment.

    Main Results:

    • Approximately 50% of ANLL patients exhibit abnormal karyotypes.
    • Common abnormalities include +8, -7, and the 8;21 translocation, often with sex chromosome loss.
    • The 15;17 translocation is highly specific for acute promyelocytic leukemia.
    • Chromosomal abnormalities typically absent in remission reappear during relapse, with +8 being a frequent evolutionary change.
    • ANLL following lymphoma treatment often shows hypodiploidy and loss of chromosomes 5 or 7.

    Conclusions:

    • Specific nonrandom chromosomal abnormalities are hallmarks of ANLL and its subtypes.
    • Karyotypic analysis is crucial for understanding ANLL pathogenesis and monitoring disease status.
    • Chromosomal evolution during relapse suggests ongoing genetic instability and potential therapeutic targets.

    Related Experiment Videos