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Newly discovered anti-inflammatory properties of the benzamides and nicotinamides

R W Pero1, B Axelsson, D Siemann

  • 1Department of Cell and Molecular Biology, University of Lund, Sweden.

Molecular and Cellular Biochemistry
|May 20, 1999
PubMed

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Physical Properties of Amines

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Electrophilic Aromatic Substitution: Nitration of Benzene

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Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
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Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
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