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Correlation between rates of brain atrophy and cognitive decline in AD
N C Fox1, R I Scahill, W R Crum
1Department of Clinical Neurology, Institute of Neurology, University College, London, UK.
Neurology
|May 20, 1999
Abstract:
Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.