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Related Experiment Videos

Lactate detection at 3T: compensating J coupling effects with BASING.

D A Kelley1, L L Wald, J M Star-Lack

  • 1Institute for Magnetic Resonance Research, University of Sydney, Australia. dougk@ziplink.net

Journal of Magnetic Resonance Imaging : JMRI
|May 20, 1999
PubMed
Summary
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Detecting lactate with in vivo 1H magnetic resonance spectroscopy can identify metabolic stress. New methods using BASING/MEGA pulses overcome signal anomalies in PRESS and STEAM sequences at higher field strengths, improving lactate detection accuracy.

Area of Science:

  • Biophysics
  • Biomedical Imaging
  • Metabolic Spectroscopy

Background:

  • In vivo 1H magnetic resonance spectroscopy (MRS) detects lactate to identify metabolic stress in tissues like brain.
  • Higher field strengths (3 and 4 T) enhance sensitivity but introduce challenges for lactate detection.
  • Anomalous J modulation in PRESS and STEAM sequences at high fields causes signal cancellation and inaccurate lactate quantification.

Purpose of the Study:

  • To describe a method for eliminating anomalous J modulation in lactate detection using BASING/MEGA water suppression pulses.
  • To improve the accuracy of in vivo lactate quantification in human tissues at higher magnetic field strengths.

Main Methods:

  • Utilized BASING/MEGA (selective echo dephasing/inversion with gradient dephasing) water suppression techniques.

Related Experiment Videos

  • Applied these methods to PRESS and STEAM sequences in single voxel and chemical shift imaging studies.
  • Investigated the impact of radiofrequency (RF) pulse bandwidth and chemical shift misregistration artifacts.

    • Main Results:

    • The BASING/MEGA method effectively eliminates signal cancellation and spatial variation of lactate signals.
    • Accurate lactate concentration determination is achieved, overcoming limitations of standard PRESS and STEAM sequences.
    • Demonstrated improved lactate detection in simulated conditions relevant to stroke and tumors.

    Conclusions:

    • BASING/MEGA water suppression is a robust technique for accurate in vivo lactate detection using 1H MRS.
    • This method enhances the reliability of identifying metabolic stress, ischemia, and necrosis.
    • Overcomes technical challenges posed by high-field MRS, improving diagnostic potential.