Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial perfusion and right ventricular function.

U P Klima1, J L Guerrero, G J Vlahakes

  • 1Cardiothoracic and Vascular Surgery, Hannover Medical School, 30623 Hannover, Germany.

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
|May 20, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiological assessment of petroleum source rocks from the Middle Magdalena Valley basin in Colombia.

Journal of environmental radioactivity·2026
Same author

Temporal trends of pollution in an estuary affected by phosphogypsum leachates and acid mine drainage: Waste management implications.

Marine pollution bulletin·2025
Same author

First full-scale application of barium carbonate as an effective dispersed alkaline substrate for sulfate removal from acid mine drainage.

The Science of the total environment·2024
Same author

Sedimentary environmental quality of a biosphere reserve estuary in southwestern Iberian Peninsula.

Marine pollution bulletin·2024
Same author

Guidelines for inhaled sedation in the ICU.

Revista espanola de anestesiologia y reanimacion·2024
Same author

Spatiotemporal evolution of U and Th isotopes in a mine effluent highly polluted by Acid Mine Drainage (AMD).

Journal of hazardous materials·2023

Adequate right ventricular (RV) myocardial blood flow is crucial for maximal RV performance. Maintaining sufficient coronary artery driving pressure is essential to prevent RV failure and optimize RV function.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanics
  • Myocardial Perfusion

Background:

  • Maximal right ventricular (RV) performance is intrinsically linked to left heart hemodynamics and subsequent coronary perfusion.
  • The influence of RV myocardial perfusion on maximal RV function remains an area requiring further investigation.

Purpose of the Study:

  • To investigate the role of right ventricular myocardial perfusion as a determinant of maximal RV function.
  • To assess the relationship between coronary perfusion pressure and RV performance under conditions of induced RV failure.

Main Methods:

  • Utilized canine isovolumic right heart preparations subjected to incremental RV volume loading until failure.
  • Measured maximal RV developed pressure (RVDP) and maximal positive RV dP/dt at controlled left ventricular output and varying mean arterial pressures (50, 80, 120 mmHg).

Related Experiment Videos

  • Quantified right coronary artery (RCA) flow throughout the experiment.

    • Main Results:

    • Maximal RVDP and RCA flow significantly increased with rising mean arterial pressures.
    • At the onset of RV failure, RCA blood flow markedly decreased compared to maximal flow levels across all tested pressures.
    • A significant correlation was observed between systemic pressure, RCA flow, and RV performance.

    Conclusions:

    • Coronary perfusion pressure is a critical determinant of maximal RV function.
    • Sufficient coronary artery driving pressure is necessary to prevent the onset of RV failure.
    • Maintaining adequate systemic pressure and RV myocardial blood flow can enhance RV functional capacity.