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A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation.

P J Boyne¹, R E Marx, M Nevins

¹Department of Oral and Maxillofacial Surgery, School of Dentistry, Loma Linda University, California, USA.

The International Journal of Periodontics & Restorative Dentistry

|February 1, 1997

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Human recombinant bone morphogenetic protein-2 on an absorbable collagen sponge (rhBMP-2/ACS) shows promising results for maxillary sinus floor augmentation. This study found significant bone growth and good safety in patients needing dental implants.

Area of Science:

Oral and Maxillofacial Surgery
Regenerative Medicine
Biomaterials Science

Background:

Maxillary sinus floor augmentation is crucial for dental implant success in patients with insufficient bone height.
Traditional bone grafting methods have limitations, including donor site morbidity and limited bone availability.
Novel biomaterials are needed to improve bone regeneration for dental implantology.

Purpose of the Study:

To evaluate the safety and technical feasibility of using human recombinant bone morphogenetic protein-2 delivered on an absorbable collagen sponge (rhBMP-2/ACS) for maxillary sinus floor augmentation.
To assess the efficacy of rhBMP-2/ACS in promoting bone growth for dental implant placement.
To compare rhBMP-2/ACS with traditional bone graft materials.

Main Methods:

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A 16-week, open-label study involving 12 patients with inadequate posterior maxillary bone height.
rhBMP-2/ACS was implanted for two-stage maxillary sinus floor augmentation, with doses ranging from 1.77 to 3.40 mg.
Computerized tomographic scans, histologic examination of bone biopsies, and clinical follow-up were used to assess outcomes.

Main Results:

Significant bone growth was observed in 11 out of 12 patients, with a mean height increase of 8.51 mm.
The rhBMP-2/ACS device was easy to handle, and no serious immunologic or adverse effects were reported.
Histologic analysis confirmed good bone quality, suitable for dental implant placement.

Conclusions:

rhBMP-2/ACS appears to be a safe and technically feasible option for maxillary sinus floor augmentation.
This biomaterial demonstrates potential as an alternative to traditional bone grafts for enhancing bone volume in the posterior maxilla.
Further research and long-term follow-up are ongoing for patients receiving dental implants.