Related Experiment Videos
Proteinuria and renal function during and after acute urinary retention
S Mustonen1, I Ala-Houhala, T L Tammela
1Division of Urology, Tampere University Hospital, Finland.
The Journal of Urology
|May 20, 1999
Summary
Acute urinary retention, often caused by benign prostatic hyperplasia, significantly impacts kidney function, leading to persistent glomerular and tubular damage. Prompt treatment is crucial to mitigate long-term renal consequences.
Area of Science:
- Nephrology
- Urology
- Internal Medicine
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in men, frequently causing bladder outlet obstruction.
- BPH can lead to acute urinary retention (AUR), posing a risk to renal function.
- The impact of AUR on kidney function requires further investigation.
Purpose of the Study:
- To investigate the effects of acute urinary retention (AUR) on renal function in men.
- To assess the persistence of renal function abnormalities after AUR relief.
Main Methods:
- Renal function was evaluated in 25 men (mean age 69 years) experiencing AUR due to bladder outlet obstruction.
- Biochemical markers of renal function were assessed during AUR and at 1 and 6 months post-relief.
- Patients with pre-existing renal disease were excluded.
Main Results:
- Albuminuria was present in 100% of patients during AUR, decreasing to 54% at 6 months.
- Elevated alpha 1-microglobulin excretion (tubular marker) was observed in 54% at presentation and 58% at 6 months.
- Elevated beta 2-microglobulin excretion (tubular marker) decreased from 17% to 9% at 6 months, while serum creatinine did not predict proteinuria.
Conclusions:
- Acute urinary retention adversely affects both glomerular and tubular renal function.
- Persistent glomerular hyperpermeability and tubular damage were noted in most patients after AUR resolution.
- These renal impairments may be linked to underlying long-term bladder outlet obstruction, highlighting the need for rapid AUR recognition and treatment.